ARG52418
anti-p90 RSK2 antibody
anti-p90 RSK2 antibody for Western blot and Human
Gene Regulation antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes p90 RSK2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Bov, Chk, Dog |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | p90 RSK2 |
| 抗原物种 | Mouse |
| 抗原 | Synthetic peptide corresponding to amino acid residues from the C-terminal region of p90 RSK2 conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | Ribosomal S6 kinase 3; S6K-alpha2; MAPKAPK-1c; MAPKAP kinase 1c; RSK; HU-2; S6K-alpha; p90RSK2; RSK-3; p90-RSK 2; MAPKAPK1C; p90-RSK3; pp90RSK3; 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; EC 2.7.11.1; Ribosomal protein S6 kinase alpha-2; RSK3; S6K-alpha-2; MAPK-activated protein kinase 1c |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | Specific for ~90k RSK2 protein. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q15349 Human Ribosomal protein S6 kinase alpha-2 |
|---|---|
| 基因名称 | RPS6KA2 |
| 全名 | ribosomal protein S6 kinase, polypeptide 2 |
| 背景介绍 | The p90 ribosomal S6 kinases (RSK)1–4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin–Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006). |
| 研究领域 | Gene Regulation antibody; Signaling Transduction antibody |
| 预测分子量 | 83 kDa |
| 翻译后修饰 | Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity). N-terminal myristoylation results in an activated kinase in the absence of added growth factors. |
检测图片 (1) Click the Picture to Zoom In
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ARG52418 anti-p90 RSK2 antibody WB image
Western blot: HeLa cell lysate showing specific immunolabeling of the ~90 kDa of RSK2 protein stained with ARG52418 anti-p90 RSK2 antibody.
