ARG54654
anti-p53DINP1 antibody
anti-p53DINP1 antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes p53DINP1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, IHC-P, WB |
| 特异性 | At least two isoforms of p53DINP1 are known to exist; this antibody will detect both isoforms. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | p53DINP1 |
| 抗原 | Synthetic peptide (14 aa) within the first 50 aa of Human p53DINP1. |
| 偶联标记 | Un-conjugated |
| 別名 | TP53DINP1; SIP; p53DINP1; Teap; Stress-induced protein; Tumor protein p53-inducible nuclear protein 1; p53-dependent damage-inducible nuclear protein 1; TP53INP1A; TP53INP1B |
应用说明
| 应用建议 |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Human Lung Tissue Lysate | ||||||||
| 实际分子量 | 30 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q80YE2 Rat Tumor protein p53-inducible nuclear protein 1 Swiss-port # Q96A56 Human Tumor protein p53-inducible nuclear protein 1 |
|---|---|
| 基因名称 | TP53INP1 |
| 全名 | tumor protein p53 inducible nuclear protein 1 |
| 背景介绍 | p53DINP1 Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse. A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks. p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-alpha and p53DINP1-beta or SIP27 and SIP18. p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress. | |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody |
| 预测分子量 | 18, 27 kDa |
检测图片 (2) Click the Picture to Zoom In
-
ARG54654 anti-p53DINP1 antibody IHC image
Immunohistochemistry: mouse liver stained with ARG54654 anti-p53DINP1 antibody at 2 μg/ml.
-
ARG54654 anti-p53DINP1 antibody WB image
Western blot: human lung tissue lysate stained with ARG54654 anti-p53DINP1 antibody at (A) 0.5 and (B) 1 μg/ml.
