ARG58948
anti-n Myc antibody
anti-n Myc antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes n Myc |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | n Myc |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human n Myc. |
| 偶联标记 | Un-conjugated |
| 別名 | NMYC; bHLHe37; MODED; Class E basic helix-loop-helix protein 37; N-myc; N-myc proto-oncogene protein; ODED |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | SH-SY5Y | ||||||||
| 实际分子量 | 45 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MYCN |
| 全名 | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog |
| 背景介绍 | This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
| 生物功能 | Positively regulates the transcription of NCYM in neuroblastoma cells. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 50 kDa |
| 翻译后修饰 | Phosphorylated by GSK3-beta which may promote its degradation. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG58948 anti-n Myc antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain stained with ARG58948 anti-n Myc antibody.
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ARG58948 anti-n Myc antibody WB image
Western blot: 25 µg of SH-SY5Y cell lysate stained with ARG58948 anti-n Myc antibody at 1:1000 dilution.
