概述

产品描述	Rabbit Polyclonal antibody recognizes mGluR2
反应物种	Hu, Ms, Rat
应用	ICC/IF, IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	mGluR2
抗原物种	Human
抗原	Synthetic peptide of Human mGluR2.
偶联标记	Un-conjugated
別名	GPRC1B; mGlu2; mGluR2; Metabotropic glutamate receptor 2; GLUR2; MGLUR2

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:50 - 1:200 IHC-P 1:50 - 1:200 WB 1:5000 - 1:10000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Mouse brain
实际分子量	~ 97 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 108068 Mouse GRM2 GeneID: 24415 Rat GRM2 GeneID: 2912 Human GRM2 Swiss-port # P31421 Rat Metabotropic glutamate receptor 2 Swiss-port # Q14416 Human Metabotropic glutamate receptor 2 Swiss-port # Q14BI2 Mouse Metabotropic glutamate receptor 2 More
基因名称	GRM2
全名	glutamate receptor, metabotropic 2
背景介绍	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
生物功能	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. [UniProt]
细胞定位	Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. [UniProt]
预测分子量	96 kDa

检测图片 (1) Click the Picture to Zoom In