ARG52339
anti-mGluR1a + mGluR5 antibody
anti-mGluR1a + mGluR5 antibody for IHC-Frozen sections,Western blot and Rat
Cancer antibody; Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes mGluR1a + mGluR5 |
|---|---|
| 反应物种 | Rat |
| 预测物种 | Hu, Ms |
| 应用 | IHC-Fr, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | mGluR1a + mGluR5 |
| 抗原物种 | Rat |
| 抗原 | Peptide from the C-terminal region of rat mGluR5 and rat mGluR1a. |
| 偶联标记 | Un-conjugated |
| 別名 | PPP1R86; mGlu5; GPRC1E; Metabotropic glutamate receptor 5; mGluR5; MGLUR5 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~125k monomer and the ~250k dimers of mGluR5 and mGluR1. Immunolabeling is blocked by preadsorption of antibody with the peptide used as antigen to geneRate the antibody. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GRM5 |
| 全名 | glutamate receptor, metabotropic 5 |
| 背景介绍 | The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004). |
| 研究领域 | Cancer antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 132 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG52339 anti-mGluR1a + mGluR5 antibody WB image
Western blot: 10 μg of HEK 293 cells expressing mGluR1a and mGluR5 showing specific immunolabeling of the ~125k monomer and the ~250k dimers of mGluR1a and mGluR5 stained with ARG52339 anti-mGluR1a + mGluR5 antibody.
