ARG56361
anti-hnRNP A1 antibody
anti-hnRNP A1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes hnRNP A1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | hnRNP A1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human hnRNP A1 |
| 偶联标记 | Un-conjugated |
| 別名 | Heterogeneous nuclear ribonucleoprotein A1; hnRNP core protein A1; hnRNP A1; Helix-destabilizing protein; ALS20; Single-strand RNA-binding protein; hnRNP-A1; HNRPA1; HNRPA1L3; IBMPFD3; ALS19 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Jurkat |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HNRNPA1 |
| 全名 | heterogeneous nuclear ribonucleoprotein A1 |
| 背景介绍 | This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. [UniProt] |
| 预测分子量 | 39 kDa |
| 翻译后修饰 | Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine. Sumoylated. |
检测图片 (3) Click the Picture to Zoom In
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ARG56361 anti-hnRNP A1 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG56361 anti-hnRNP A1 antibody.
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ARG56361 anti-hnRNP A1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain stained with ARG56361 anti-hnRNP A1 antibody at 1:100 dilution.
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ARG56361 anti-hnRNP A1 antibody WB image
Western blot: Jurkat cell lysate stained with ARG56361 anti-hnRNP A1 antibody.
