概述

产品描述	Rabbit Polyclonal antibody recognizes eIF3E
反应物种	Hu, Zfsh
预测物种	Ms, Rat, Bov, Chk, Mk, Xenopus
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	eIF3E
抗原物种	Human
抗原	KLH-conjugated synthetic peptide corresponding to aa. 248-276 of Human eIF3E.
偶联标记	Un-conjugated
別名	Viral integration site protein INT-6 homolog; EIF3-P48; EIF3S6; eIF3e; Eukaryotic translation initiation factor 3 subunit 6; eIF3-p46; INT6; Eukaryotic translation initiation factor 3 subunit E; eIF-3 p48

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	K562

属性

形式	Liquid
纯化	Purification with Protein A and immunogen peptide.
缓冲液	PBS and 0.09% (W/V) Sodium azide.
抗菌剂	0.09% (W/V) Sodium azide.
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 3646 Human EIF3E Swiss-port # P60228 Human Eukaryotic translation initiation factor 3 subunit E
基因名称	EIF3E
全名	eukaryotic translation initiation factor 3, subunit E
生物功能	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. [UniProt]
细胞定位	Cytoplasm. Nucleus, PML body. [UniProt]
预测分子量	52 kDa

检测图片 (1) Click the Picture to Zoom In