anti-delta 1 Catenin antibody [SQab20216]
anti-delta 1 Catenin antibody [SQab20216] for IHC-Formalin-fixed paraffin-embedded sections and Human
|产品描述||Recombinant Rabbit Monoclonal antibody [SQab20216] recognizes delta 1 Catenin|
|靶点名称||delta 1 Catenin|
|抗原||Synthetic peptide within aa. 900-1000 of Human delta 1 Catenin.|
|別名||p120 catenin; p120; CAS; P120CAS; CTNND; p120(CAS); cas; Catenin delta-1; Cadherin-associated Src substrate; p120(CTN); P120CTN; ctn|
|应用说明||IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C - 25°C) for 30 minutes.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|纯化||Purification with Protein A.|
|缓冲液||PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.|
|抗菌剂||0.01% Sodium azide|
|稳定剂||40% Glycerol and 0.05% BSA|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
|全名||catenin (cadherin-associated protein), delta 1|
|背景介绍||This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]|
|生物功能||Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. [UniProt]|
|细胞定位||Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187). Isoform 1A: Nucleus. Isoform 2A: Nucleus. Isoform 3A: Nucleus. [UniProt]|
|翻译后修饰||Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ. [UniProt]|
检测图片 (1) Click the Picture to Zoom In
ARG66803 anti-delta 1 Catenin antibody [SQab20216] IHC-P image
Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded Human colon tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66803 anti-delta 1 Catenin antibody [SQab20216].