ARG40468
anti-c-Myb antibody [1279CT309.289]
anti-c-Myb antibody [1279CT309.289] for Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes c-Myb |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1279CT309.289 |
| 同位型 | IgG1, kappa |
| 靶点名称 | c-Myb |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated recombinant protein corresponding to aa. 1-185 of Human c-Myb. |
| 偶联标记 | Un-conjugated |
| 別名 | Transcriptional activator Myb; Proto-oncogene c-Myb; c-myb_CDS; c-myb; Cmyb; efg |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Jurkat |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MYB |
| 全名 | v-myb avian myeloblastosis viral oncogene homolog |
| 背景介绍 | This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] |
| 生物功能 | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 63 - 85 kDa |
| 翻译后修饰 | Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG40468 anti-c-Myb antibody WB image
Western blot: 20 µg of Jurkat whole cell lysate stained with ARG40468 anti-c-Myb antibody at 1:2000 dilution.
