ARG44617
anti-alpha 2 Macroglobulin antibody
anti-alpha 2 Macroglobulin antibody for Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes alpha 2 Macroglobulin |
|---|---|
| 反应物种 | Hu |
| 应用 | IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2b |
| 靶点名称 | alpha 2 Macroglobulin |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | A2M; Alpha-2-Macroglobulin; CPAMD5; FWP007; S863-7; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 5; Alpha-2-M; A2MD |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | A2M |
| 全名 | Alpha-2-Macroglobulin |
| 背景介绍 | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016] |
| 生物功能 | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 163 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Isopeptide bond, Thioester bond. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG44617 anti-alpha 2 Macroglobulin antibody IP image
Immunoprecipitation: HepG2 lysate immunoprecipitated with 2.5 µg ARG44617 anti-alpha 2 Macroglobulin antibody.
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ARG44617 anti-alpha 2 Macroglobulin antibody IHC-P image
Immunohistochemistry: Human plasma stained with ARG44617 anti-alpha 2 Macroglobulin antibody at 1 µg/mL dilution.
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ARG44617 anti-alpha 2 Macroglobulin antibody IHC-P image
Immunohistochemistry: HepG2 stained with ARG44617 anti-alpha 2 Macroglobulin antibody at 1 µg/mL dilution.
