ARG41453
anti-alpha 2 Macroglobulin antibody
anti-alpha 2 Macroglobulin antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes alpha 2 Macroglobulin |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | alpha 2 Macroglobulin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human alpha 2 Macroglobulin. |
| 偶联标记 | Un-conjugated |
| 別名 | CPAMD5; Alpha-2-macroglobulin; S863-7; FWP007; Alpha-2-M; A2MD; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human plasma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | A2M |
| 全名 | alpha-2-macroglobulin |
| 背景介绍 | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] |
| 生物功能 | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 163 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG41453 anti-alpha 2 Macroglobulin antibody WB image
Western blot: Human plasma lysate stained with ARG41453 anti-alpha 2 Macroglobulin antibody.
