ARG45869
anti-Zebrafish DUSP4 antibody
anti-Zebrafish DUSP4 antibody for IHC-Formalin-fixed paraffin-embedded sections and Zebrafish
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DUSP4 |
|---|---|
| 反应物种 | Zfsh |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DUSP4 |
| 抗原物种 | Zebrafish |
| 偶联标记 | Un-conjugated |
| 別名 | DUSP4; dual specificity phosphatase 4; MKP-2; MAP kinase phosphatase 2; MKP2; EC 3.1.3.16; HVH2; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; EC 3.1.3.48; Mitogen-activated protein kinase phosphatase 2; TYP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | 0.02M PBS, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% glycerol |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | DUSP4 |
|---|---|
| 全名 | dual specificity phosphatase 4 |
| 背景介绍 | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 43 kDa |
| 翻译后修饰 | Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45869 anti-Zebrafish DUSP4 antibody IHC-P image
Immunohistochemistry: Zebrafish heart stained with ARG45869 anti-Zebrafish DUSP4 antibody at 2 μg/ml dilution.
