ARG45432
anti-ZNRF3 antibody
anti-ZNRF3 antibody for Flow cytometry,ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ZNRF3 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ZNRF3 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human ZNRF3. |
| 偶联标记 | Un-conjugated |
| 別名 | ZNRF3; Zinc And Ring Finger 3; RNF203; BK747E2.3; KIAA1133; RING-Type E3 Ubiquitin Transferase ZNRF3; E3 Ubiquitin-Protein Ligase ZNRF3; Zinc/RING Finger Protein 3; RING Finger Protein 203; FLJ22057; Novel C3HC4 Type Zinc Finger (Ring Finger); CTA-292E10.6; EC 2.3.2.27 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 130 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ZNRF3 |
| 全名 | Zinc And Ring Finger 3 |
| 背景介绍 | Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024] |
| 生物功能 | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone. [UniProt] |
| 细胞定位 | Cell membrane. [UniProt] |
| 预测分子量 | 101 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG45432 anti-ZNRF3 antibody ICC/IF image
Immunofluorescence: U2OS stained with ARG45432 anti-ZNRF3 antibody at 5 μg/ml dilution.
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ARG45432 anti-ZNRF3 antibody WB image
Western blot: CACO-2 stained with ARG45432 anti-ZNRF3 antibody at 0.5 μg/ml dilution.
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ARG45432 anti-ZNRF3 antibody FACS image
Flow Cytometry: PC-3 stained with ARG45432 anti-ZNRF3 antibody at 1 µg/10^6 cells dilution.
