ARG46675
anti-ZGPAT antibody
anti-ZGPAT antibody for Western blot and Human
概述
| 产品描述 | Chicken Polyclonal antibody recognizes ZGPAT |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Chicken |
| 克隆 | Polyclonal |
| 同位型 | IgY |
| 靶点名称 | ZGPAT |
| 抗原物种 | Human |
| 抗原 | A 15 amino acid synthetic peptide within the last 50 amino acids of human ZGPAT. |
| 偶联标记 | Un-conjugated |
| 別名 | zinc finger, CCCH-type with G patch domain; ZGPAT; ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847; ZIP; Zinc finger CCCH-type with G patch domain-containing protein; G patch domain-containing protein 6 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -725°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8N5A5 Human Zinc finger CCCH-type with G patch domain-containing protein |
|---|---|
| 基因名称 | ZGPAT |
| 全名 | zinc finger, CCCH-type with G patch domain |
| 背景介绍 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| 生物功能 | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 57 kDa |
| 翻译后修饰 | Phosphoprotein; Ubl conjugation; Acetylation. [UniProt] |
