ARG43294

anti-ZEB1 antibody

anti-ZEB1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

概述

产品描述 Rabbit Polyclonal antibody recognizes ZEB1
反应物种 Hu, Ms, Rat
应用 ICC/IF, IHC-P
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 ZEB1
抗原物种 Human
抗原 Recombinant fusion protein corresponding to aa. 1-260 of Human ZEB1 (NP_001167567.1).
偶联标记 Un-conjugated
別名 Transcription factor 8; DELTAEF1; PPCD3; TCF-8; AREB6; BZP; TCF8; NIL-2-A zinc finger protein; FECD6; NIL2A; Zinc finger E-box-binding homeobox 1; Negative regulator of IL2; ZFHX1A; ZFHEP

应用说明

应用建议
应用 推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
纯化 Affinity purified.
缓冲液 PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 21417 Mouse ZEB1

GeneID: 6935 Human ZEB1

Swiss-port # P37275 Human Zinc finger E-box-binding homeobox 1

Swiss-port # Q64318 Mouse Zinc finger E-box-binding homeobox 1

基因名称 ZEB1
全名 zinc finger E-box binding homeobox 1
背景介绍 This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
生物功能 Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. [UniProt]
细胞定位 Nucleus. [UniProt]
预测分子量 124 kDa

检测图片 (2) Click the Picture to Zoom In

  • ARG43294 anti-ZEB1 antibody ICC/IF image

    Immunofluorescence: U2OS cells stained with ARG43294 anti-ZEB1 antibody.

  • ARG43294 anti-ZEB1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat testis tissue stained with ARG43294 anti-ZEB1 antibody at 1:200 dilution.