ARG57824
anti-XRCC1 antibody
anti-XRCC1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes XRCC1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | XRCC1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human XRCC1. |
| 偶联标记 | Un-conjugated |
| 別名 | X-ray repair cross-complementing protein 1; DNA repair protein XRCC1; RCC |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | XRCC1 |
| 全名 | X-ray repair complementing defective repair in Chinese hamster cells 1 |
| 背景介绍 | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] |
| 生物功能 | Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 69 kDa |
| 翻译后修饰 | Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF. Sumoylated. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG57824 anti-XRCC1 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG57824 anti-XRCC1 antibody.
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ARG57824 anti-XRCC1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human testis tissue stained with ARG57824 anti-XRCC1 antibody.
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ARG57824 anti-XRCC1 antibody WB image
Western blot: HeLa cell lysate stained with ARG57824 anti-XRCC1 antibody.
