ARG57763
anti-XPA antibody [71H3]
anti-XPA antibody [71H3] for Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [71H3] recognizes XPA |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 71H3 |
| 同位型 | IgG1, kappa |
| 靶点名称 | XPA |
| 抗原物种 | Human |
| 抗原 | Recombinant protein around aa. 1-273 of Human XPA. |
| 偶联标记 | Un-conjugated |
| 別名 | XP1; XPAC; Xeroderma pigmentosum group A-complementing protein; DNA repair protein complementing XP-A cells |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P23025 Human DNA repair protein complementing XP-A cells |
|---|---|
| 基因名称 | XPA |
| 全名 | xeroderma pigmentosum, complementation group A |
| 背景介绍 | This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
| 生物功能 | Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. [UniProt] |
| 预测分子量 | 31 kDa |
| 翻译后修饰 | ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage. Ubiquitinated by HERC2 leading to degradation by the proteasome. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG57763 anti-XPA antibody [71H3] WB image
Western blot: 40 µg of SW480, K562, MCF7, LNCaP and Raji cell lysates stained with ARG57763 anti-XPA antibody [71H3] at 1:1000 dilution.
