ARG44768
anti-WASL antibody
anti-WASL antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human,Mouse
概述
| 产品描述 | Mouse Monoclonal antibody recognizes WASL |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a |
| 靶点名称 | WASL |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | WASPB; N-WASP; NWASP; Neural Wiskott-Aldrich syndrome protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O00401 Human Neural Wiskott-Aldrich syndrome protein Swiss-port # Q91YD9 Mouse Neural Wiskott-Aldrich syndrome protein |
|---|---|
| 基因名称 | WASL |
| 全名 | Wiskott-Aldrich syndrome-like |
| 背景介绍 | This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013] |
| 生物功能 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm. [UniProt] |
| 预测分子量 | 93 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG44768 anti-WASL antibody IHC-P image
Immunohistochemistry: Human small intestine stained with ARG44768 anti-WASL antibody at 5 µg/mL dilution.
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ARG44768 anti-WASL antibody IP image
Immunoprecipitation: Mouse brain lysate immunoprecipitated with 2.5 µg of ARG44768 anti-WASL antibody.
