ARG41409
anti-VLDL Receptor antibody [VLDLR/1337]
anti-VLDL Receptor antibody [VLDLR/1337] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [VLDLR/1337] recognizes VLDL Receptor |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | VLDLR/1337 |
| 同位型 | IgG1, kappa |
| 靶点名称 | VLDL Receptor |
| 抗原物种 | Human |
| 抗原 | Recombinant partial protein around the C-terminal region of Human VLDL Receptor. |
| 偶联标记 | Un-conjugated |
| 別名 | VLDLRCH; VLDL-R; VLDL receptor; CARMQ1; Very low-density lipoprotein receptor; CAMRQ1; CHRMQ1 |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Tris with 1 mM EDTA (pH 9.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P98155 Human Very low-density lipoprotein receptor |
|---|---|
| 基因名称 | VLDLR |
| 全名 | very low density lipoprotein receptor |
| 背景介绍 | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009] |
| 生物功能 | Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 96 kDa |
| 翻译后修饰 | Ubiquitinated at Lys-839 by MYLIP leading to degradation. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG41409 anti-VLDL Receptor antibody [VLDLR/1337] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human pancreas tissue stained with ARG41409 anti-VLDL Receptor antibody [VLDLR/1337]. Antigen Retrieval: Boil tissue section in 10 mM Tris with 1 mM EDTA (pH 9.0) for 10-20 min, followed by cooling at RT for 20 min.
