概述

产品描述	Rabbit Polyclonal antibody recognizes VAMP2
反应物种	Hu, Ms, Rat
应用	FACS, ICC/IF, IP, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	VAMP2
抗原物种	Human
抗原	Synthetic peptide derived from Human VAMP2.
偶联标记	Un-conjugated
別名	SYB2; Synaptobrevin-2; Vesicle-associated membrane protein 2; VAMP-2

应用说明

应用建议	应用 推荐稀释比 FACS 1:50 ICC/IF 1:50 - 1:200 IP 1:50 WB 1:1000 - 1:5000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 22318 Mouse VAMP2 GeneID: 24803 Rat VAMP2 GeneID: 6844 Human VAMP2 Swiss-port # P63027 Human Vesicle-associated membrane protein 2 Swiss-port # P63044 Mouse Vesicle-associated membrane protein 2 Swiss-port # P63045 Rat Vesicle-associated membrane protein 2 More
基因名称	VAMP2
全名	vesicle-associated membrane protein 2 (synaptobrevin 2)
背景介绍	The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
生物功能	Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. [UniProt]
细胞定位	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane. Note=Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651). [UniProt]
预测分子量	13 kDa
翻译后修饰	Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2. [UniProt]

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