ARG63117
anti-Ubinuclein 1 antibody [UBN1-02]
anti-Ubinuclein 1 antibody [UBN1-02] for Immunoprecipitation,Western blot and Human
Gene Regulation antibody; Microbiology and Infectious Disease antibody
概述
| 产品描述 | Mouse Monoclonal antibody [UBN1-02] recognizes Ubinuclein 1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IP, WB |
| 特异性 | The clone UBN1-02 recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | UBN1-02 |
| 同位型 | IgG |
| 靶点名称 | Ubinuclein 1 |
| 抗原 | Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1. |
| 偶联标记 | Un-conjugated |
| 別名 | HIRA-binding protein; Ubiquitously expressed nuclear protein; Ubinuclein-1; VT; VT4; Protein VT4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | WB: HeLa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | UBN1 |
| 全名 | ubinuclein 1 |
| 背景介绍 | Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density. |
| 生物功能 | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. [UniProt] |
| 研究领域 | Gene Regulation antibody; Microbiology and Infectious Disease antibody |
| 预测分子量 | 122 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG63117 anti-Ubinuclein 1 antibody [UBN1-02] WB image
Western blot: HeLa cell nuclear fraction stained with ARG63117 anti-Ubinuclein 1 antibody [UBN1-02].
