ARG67023
anti-UTRN / Utrophin antibody
anti-UTRN / Utrophin antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes UTRN / Utrophin |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | UTRN / Utrophin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to a region of Human UTRN / Utrophin. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Utrophin |
| 別名 | Utrophin; DRP1; DMDL; DRP; Dystrophin-Related Protein; Utrophin (Homologous To Dystrophin); DRP-1 |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen retrieval: boil tissue sections in 10 mM citrate buffer (pH 6.0) for 10-20 min and allow samples to cool to RT before staining. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | UTRN |
| 全名 | utrophin |
| 背景介绍 | This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | May play a role in anchoring the cytoskeleton to the plasma membrane. [UniProt] |
| 细胞定位 | Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Postsynaptic cell membrane; Synapse. [UniProt] |
| 预测分子量 | 395 kDa |
| 翻译后修饰 | Phosphoprotein; Showing features for chain, modified residue. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG67023 anti-UTRN / Utrophin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil tissue was stained with ARG67023 anti-UTRN / Utrophin antibody at 1:200 dilution. Antigen Retrieval: Boil tissue section in Tris-EDTA (pH 9.0) for 20 min.
