概述

产品描述	Rabbit Polyclonal antibody recognizes USP1
反应物种	Hu
预测物种	Ms, Bov
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	USP1
抗原物种	Human
抗原	KLH-conjugated synthetic peptide corresponding to aa. 662-690 (C-terminus) of Human USP1.
偶联标记	Un-conjugated
別名	Ubiquitin-specific-processing protease 1; Ubiquitin carboxyl-terminal hydrolase 1; Ubiquitin thioesterase 1; Deubiquitinating enzyme 1; hUBP; EC 3.4.19.12

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	CEM

属性

形式	Liquid
纯化	Purification with Protein A and immunogen peptide.
缓冲液	PBS and 0.09% (W/V) Sodium azide
抗菌剂	0.09% (W/V) Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 7398 Human USP1 Swiss-port # O94782 Human Ubiquitin carboxyl-terminal hydrolase 1
基因名称	USP1
全名	ubiquitin specific peptidase 1
背景介绍	This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
生物功能	Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. [UniProt]
细胞定位	Nucleus.
研究领域	Cell Biology and Cellular Response antibody; Gene Regulation antibody
预测分子量	88 kDa
翻译后修饰	Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis. Ubiquitinated; leading to its subsequent proteasomal degradation.

检测图片 (1) Click the Picture to Zoom In