ARG59528
anti-UNG antibody
anti-UNG antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes UNG |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | UNG |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-313 of Human UNG (NP_550433.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Uracil-DNA glycosylase; HIGM4; HIGM5; UNG1; UNG2; UNG15; UDG; DGU; EC 3.2.2.27 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa | ||||||
| 实际分子量 | 35 kDa, 40 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | UNG |
| 全名 | uracil DNA glycosylase |
| 背景介绍 | This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010] |
| 生物功能 | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. [UniProt] |
| 细胞定位 | Isoform 1: Mitochondrion. Isoform 2: Nucleus. [UniProt] |
| 预测分子量 | Isoform 1: 34 kDa Isoform 2: 35 kDa |
| 翻译后修饰 | Isoform 1 is processed by cleavage of a transit peptide. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG59528 anti-UNG antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human stomach stained with ARG59528 anti-UNG antibody at 1:100 dilution.
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ARG59528 anti-UNG antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG59528 anti-UNG antibody at 1:1000 dilution.
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ARG59528 anti-UNG antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG59528 anti-UNG antibody at 1:100 dilution.
