ARG64871
anti-UNC5C antibody
anti-UNC5C antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Developmental Biology antibody; Neuroscience antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes UNC5C |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Dog |
| 应用 | ICC/IF, IHC-P |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | UNC5C |
| 抗原物种 | Human |
| 抗原 | NCTVSEEPTGID |
| 偶联标记 | Un-conjugated |
| 別名 | UNC5H3; Protein unc-5 homolog C; Protein unc-5 homolog 3; Netrin receptor UNC5C |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: In Citrate buffer. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] |
| 研究领域 | Developmental Biology antibody; Neuroscience antibody |
| 预测分子量 | 103 kDa |
| 翻译后修饰 | Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent. |
检测图片 (2) Click the Picture to Zoom In
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ARG64871 anti-UNC5C antibody IHC image
Immunohistochemistry Mouse Pancreas stained with ARG64871 anti-UNC5C antibody (50ug/ml). Citrate antigen retrieval. Detected by immunofluorescence.
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ARG64871 anti-UNC5C antibody IHC-P image
Immunohistochemistry: paraffin embedded Human Cerebral Cortex. (Steamed antigen retrieval with citrate buffer pH 6) stained with ARG64871 anti-UNC5C antibody at 3.8 µg/ml dilution followed by AP-staining.
