概述

产品描述	Mouse Monoclonal antibody recognizes UBR1
反应物种	Hu
应用	WB
宿主	Mouse
克隆	Monoclonal
同位型	IgG
靶点名称	UBR1
抗原物种	Human
偶联标记	Un-conjugated
別名	UBR1; Ubiquitin Protein Ligase E3 Component N-Recognin1; Ubiquitin-Protein Ligase E3-Alpha-1; Ubiquitin-Protein Ligase E3-Alpha-I; E3 Ubiquitin-Protein Ligase UBR1; N-Recognin-1; RING-Type E3 Ubiquitin Transferase UBR1; Ubiquitin-Protein Ligase E3-Alpha; Ubiquitin Ligase E3 Alpha-I; EC2.3.2.27; E3a Ligase; JBS

应用说明

应用建议	应用 推荐稀释比 WB 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Protein A purification
缓冲液	PBS with0.09% sodium azide
抗菌剂	0.09% sodium azide
存放说明	For continuous use, store undiluted antibody at2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 197131 Human UBR1 Swiss-port # Q8IWV7 Human E3 ubiquitin-protein ligase UBR1
基因名称	UBR1
全名	Ubiquitin Protein Ligase E3 Component N-Recognin1
背景介绍	The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul2008]
生物功能	Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. [Uniprot]
细胞定位	Cytoplasm. [Uniprot]
翻译后修饰	Acetylation, Phosphoprotein. [Uniprot]

检测图片 (1) Click the Picture to Zoom In