ARG41575
anti-Tyrosinase antibody
anti-Tyrosinase antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Tyrosinase |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Tyrosinase |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 20-340 of Human Tyrosinase (NP_000363.1). |
| 偶联标记 | Un-conjugated |
| 別名 | SHEP3; SK29-AB; Tumor rejection antigen AB; ATN; EC 1.14.18.1; Tyrosinase; LB24-AB; OCA1A; OCA1; Monophenol monooxygenase; OCAIA; CMM8 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse liver | ||||||||
| 实际分子量 | ~ 72 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TYR |
| 全名 | tyrosinase |
| 背景介绍 | The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008] |
| 生物功能 | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. [UniProt] |
| 细胞定位 | Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. [UniProt] |
| 预测分子量 | 60 kDa |
| 翻译后修饰 | Glycosylated. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG41575 anti-Tyrosinase antibody IHC image
Immunohistochemistry: Rat skin tissue stained with ARG41575 anti-Tyrosinase antibody at 1:100 dilution.
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ARG41575 anti-Tyrosinase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat heart tissue stained with ARG41575 anti-Tyrosinase antibody at 1:100 dilution.
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ARG41575 anti-Tyrosinase antibody WB image
Western blot: 25 µg of Mouse liver lysate stained with ARG41575 anti-Tyrosinase antibody at 1:1000 dilution.
