ARG54470
anti-Trypsin antibody [404]
anti-Trypsin antibody [404] for ELISA and Human
Cell Biology and Cellular Response antibody
概述
| 产品描述 | Mouse Monoclonal antibody [404] recognizes Trypsin |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | These antibodies recognize human pancreatic trypsin. They do not crossreact with human pancreatic chymotrypsin. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 404 |
| 同位型 | IgG2b |
| 靶点名称 | Trypsin |
| 抗原物种 | Human |
| 抗原 | Purified human pancreatic trypsin. |
| 偶联标记 | Un-conjugated |
| 別名 | Trypsin I; TRY4; TRY1; Serine protease 1; EC 3.4.21.4; Cationic trypsinogen; Trypsin-1; TRYP1; TRP1; Beta-trypsin |
应用说明
| 应用说明 | These antibodies may be used in ELISA to detect and quantitate pancreatic trypsin. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G-purified |
| 缓冲液 | PBS (pH 7.4) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRSS1 |
| 全名 | protease, serine, 1 (trypsin 1) |
| 背景介绍 | This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008] |
| 生物功能 | Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122. Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins. |
