ARG59778
anti-Tropomyosin 2 antibody
anti-Tropomyosin 2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Tropomyosin 2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Tropomyosin 2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human Tropomyosin 2. |
| 偶联标记 | Un-conjugated |
| 別名 | Tropomyosin beta chain; Beta-tropomyosin; TMSB; AMCD1; NEM4; HEL-S-273; DA1; DA2B; Tropomyosin-2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | Mouse lung and SW620 | ||||||||||
| 实际分子量 | 36 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TPM2 |
| 全名 | tropomyosin 2 (beta) |
| 背景介绍 | This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] |
| 生物功能 | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). [UniProt] |
| 细胞定位 | Cytoplasm, cytoskeleton. Note=Associates with F-actin stress fibers. [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity). [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG59778 anti-Tropomyosin 2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat testis stained with ARG59778 anti-Tropomyosin 2 antibody at 1:200 dilution.
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ARG59778 anti-Tropomyosin 2 antibody WB image
Western blot: 25 µg of Mouse lung and SW620 cell lysate stained wtih ARG59778 anti-Tropomyosin 2 antibody at 1:400 dilution.
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ARG59778 anti-Tropomyosin 2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human rectal cancer stained with ARG59778 anti-Tropomyosin 2 antibody at 1:200 dilution.
