ARG66849
anti-TrkC phospho (Tyr516) antibody
anti-TrkC phospho (Tyr516) antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TrkC phospho (Tyr516) |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | This antibody detects endogenous levels of TrkC protein only when phosphorylated at Tyr516. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TrkC |
| 抗原物种 | Human |
| 抗原 | Phosphospecific peptide around Tyr516 (aa. 482-531) of Human TrkC. |
| 偶联标记 | Un-conjugated |
| 別名 | TRKC; Neurotrophic tyrosine kinase receptor type 3; Trk-C; TrkC tyrosine kinase; NT-3 growth factor receptor; GP145-TrkC; EC 2.7.10.1; gp145(trkC) |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa + serum | ||||||
| 实际分子量 | ~ 150 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NTRK3 |
| 全名 | neurotrophic tyrosine kinase, receptor, type 3 |
| 背景介绍 | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| 生物功能 | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 94 kDa |
| 翻译后修饰 | Ligand-mediated auto-phosphorylation. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
-
ARG66849 anti-TrkC phospho (Tyr516) antibody WB image
Western blot: HeLa cells treated with serum (20% for 15 min). Cell lysates were stained with ARG66849 anti-TrkC phospho (Tyr516) antibody.
-
ARG66849 anti-TrkC phospho (Tyr516) antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human brain tissue stained with ARG66849 anti-TrkC phospho (Tyr516) antibody. The picture on the right is blocked with the phospho peptide.
