ARG57298
anti-Transthyretin / Prealbumin antibody
anti-Transthyretin / Prealbumin antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Transthyretin / Prealbumin |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Transthyretin / Prealbumin |
| 抗原物种 | Human |
| 抗原 | Recombinant Protein of Human Transthyretin / Prealbumin. |
| 偶联标记 | Un-conjugated |
| 別名 | TBPA; HEL111; ATTR; CTS; Transthyretin; CTS1; PALB; HsT2651; Prealbumin |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | U251 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TTR |
| 全名 | transthyretin |
| 背景介绍 | This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009] |
| 生物功能 | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. [UniProt] |
| 预测分子量 | 16 kDa |
| 翻译后修饰 | Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. |
检测图片 (2) Click the Picture to Zoom In
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ARG57298 anti-Transthyretin / Prealbumin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse lung stained with ARG57298 anti-Transthyretin / Prealbumin antibody at 1:100 dilution.
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ARG57298 anti-Transthyretin / Prealbumin antibody WB image
Western blot: U251 cell lysate stained with ARG57298 anti-Transthyretin / Prealbumin antibody.
