ARG56416
anti-Tollip antibody
anti-Tollip antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Tollip |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Tollip |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human Tollip. |
| 偶联标记 | Un-conjugated |
| 別名 | Toll-interacting protein; IL-1RAcPIP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | SW480 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TOLLIP |
| 全名 | toll interacting protein |
| 背景介绍 | This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011] |
| 生物功能 | Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. [UniProt] |
| 预测分子量 | 30 kDa |
| 翻译后修饰 | Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products. |
检测图片 (3) Click the Picture to Zoom In
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ARG56416 anti-Tollip antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG56416 anti-Tollip antibody.
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ARG56416 anti-Tollip antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human stomach stained with ARG56416 anti-Tollip antibody at 1:200 dilution.
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ARG56416 anti-Tollip antibody WB image
Western blot: SW480 cell lysate stained with ARG56416 anti-Tollip antibody.
