ARG40989
anti-Tissue Factor Pathway Inhibitor antibody
anti-Tissue Factor Pathway Inhibitor antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Tissue Factor Pathway Inhibitor |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Tissue Factor Pathway Inhibitor |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 261-280 of Human Tissue Factor Pathway Inhibitor (QECLRACKKGFIQRISKGGL). |
| 偶联标记 | Un-conjugated |
| 別名 | TFI; Lipoprotein-associated coagulation inhibitor; LACI; EPI; TFPI1; Tissue factor pathway inhibitor; TFPI; Extrinsic pathway inhibitor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TFPI |
| 全名 | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| 背景介绍 | This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008] |
| 生物功能 | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. [UniProt] |
| 细胞定位 | Isoform Alpha: Secreted. Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor. [UniProt] |
| 预测分子量 | 35 kDa |
| 翻译后修饰 | O-glycosylated. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG40989 anti-Tissue Factor Pathway Inhibitor antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human placenta tissue stained with ARG40989 anti-Tissue Factor Pathway Inhibitor antibody.
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ARG40989 anti-Tissue Factor Pathway Inhibitor antibody WB image
Western blot: 40 µg of SMMC-7721 whole cell lysate stained with ARG40989 anti-Tissue Factor Pathway Inhibitor antibody at 0.5 µg/ml dilution.
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ARG40989 anti-Tissue Factor Pathway Inhibitor antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG40989 anti-Tissue Factor Pathway Inhibitor antibody.
