ARG55981
anti-Thyroglobulin antibody [2H11]
anti-Thyroglobulin antibody [2H11] for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [2H11 ] recognizes Thyroglobulin |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 2H11 |
| 同位型 | IgG1, kappa |
| 靶点名称 | Thyroglobulin |
| 抗原物种 | Human |
| 抗原 | Human thyroid follicular cells. |
| 偶联标记 | Un-conjugated |
| 別名 | AITD3; Tg; TGN; Thyroglobulin |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | Antigen retrieval for IHC-P: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TG |
| 全名 | thyroglobulin |
| 背景介绍 | Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009] |
| 生物功能 | Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). [UniProt] |
| 细胞定位 | Cytoplasmic and secreted |
| 预测分子量 | 305 kDa |
| 翻译后修饰 | Sulfated tyrosines are desulfated during iodination. |
检测图片 (1) Click the Picture to Zoom In
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ARG55981 anti-Thyroglobulin antibody [2H11] IHC-P image
Immunohistochemistry: thyroid tissue stained with ARG55981 anti-Thyroglobulin antibody [2H11].
