ARG44594
anti-Thrombomodulin antibody [M80] (APC)
anti-Thrombomodulin antibody [M80] (APC) for Flow cytometry and Human
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody recognizes Thrombomodulin |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | M80 |
| 同位型 | IgG1 |
| 靶点名称 | Thrombomodulin |
| 抗原物种 | Human |
| 偶联标记 | APC |
| 別名 | THBD; Thrombomodulin; THRM; Fetomodulin; BDCA-3; CD141; CD141 Antigen; TM; THPH12; AHUS6; BDCA3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified antibody is conjugated with activated allophycocyanin (APC), and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | THBD |
| 全名 | thrombomodulin |
| 背景介绍 | The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] |
| 生物功能 | Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. [UniProt] |
| 细胞定位 | Membrane. [UniProt] |
| 预测分子量 | 60 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Hydroxylation, Proteoglycan. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG44594 anti-Thrombomodulin antibody [M80] (APC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG44594 anti-Thrombomodulin antibody [M80] (APC) at 10 μl/ 100 μl dilution.
