ARG41392
anti-TYROBP / DAP12 antibody
anti-TYROBP / DAP12 antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TYROBP / DAP12 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TYROBP / DAP12 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the middle region of Human TYROBP / DAP12. (within the following region: IALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLN) |
| 偶联标记 | Un-conjugated |
| 別名 | TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; DAP12; PLOSL; KARAP; KAR-associated protein; Killer-activating receptor-associated protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 | ||||
| 实际分子量 | ~ 16 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O43914 Human TYRO protein tyrosine kinase-binding protein Swiss-port # O54885 Mouse TYRO protein tyrosine kinase-binding protein |
|---|---|
| 基因名称 | TYROBP |
| 全名 | TYRO protein tyrosine kinase binding protein |
| 背景介绍 | This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010] |
| 生物功能 | Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 12 kDa |
| 翻译后修饰 | Tyrosine phosphorylated. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG41392 anti-TYROBP / DAP12 antibody WB image
Western blot: HepG2 whole cell lysate stained with ARG41392 anti-TYROBP / DAP12 antibody at 1 µg/ml dilution.
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ARG41392 anti-TYROBP / DAP12 antibody WB image
Western blot: Mouse testis lysate stained with ARG41392 anti-TYROBP / DAP12 antibody at 1 µg/ml dilution.
