ARG51647
anti-TYK2 phospho (Tyr1054) antibody
anti-TYK2 phospho (Tyr1054) antibody for Western blot and Human,Mouse,Rat
Signaling Transduction antibody
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TYK2 phospho (Tyr1054) |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TYK2 |
| 抗原物种 | Human |
| 抗原 | Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R) derived from Human TYK2. |
| 偶联标记 | Un-conjugated |
| 別名 | JTK1; IMD35; Non-receptor tyrosine-protein kinase TYK2; EC 2.7.10.2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic phosphopeptide. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. In addition, non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 缓冲液 | PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P29597 Human Non-receptor tyrosine-protein kinase TYK2 |
|---|---|
| 基因名称 | TYK2 |
| 全名 | tyrosine kinase 2 |
| 背景介绍 | TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. |
| 生物功能 | Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. [UniProt] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 134 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG51647 anti-TYK2 phospho (Tyr1054) antibody WB image
Western blot: Extracts from HT29 cells untreated(lane 1) or treated with Anisomycin(lane 2) stained with ARG51647 anti-TYK2 phospho (Tyr1054) antibody.
文献引用
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
WB / Rat
