概述

产品描述	Rabbit Polyclonal antibody recognizes TXNIP
反应物种	Hu, Ms, Rat
应用	ICC/IF, IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	TXNIP
抗原物种	Human
抗原	Synthetic peptide derived from Human TXNIP.
偶联标记	Un-conjugated
別名	Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1; Thioredoxin-interacting protein; HHCPA78; VDUP1; THIF; EST01027

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:50 - 1:200 IHC-P 1:50 - 1:200 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	BxPC-3

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 10628 Human TXNIP GeneID: 117514 Rat TXNIP GeneID: 56338 Mouse TXNIP Swiss-port # Q5M7W1 Rat Thioredoxin-interacting protein Swiss-port # Q8BG60 Mouse Thioredoxin-interacting protein Swiss-port # Q9H3M7 Human Thioredoxin-interacting protein More
基因名称	TXNIP
全名	thioredoxin interacting protein
背景介绍	This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
生物功能	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). [UniProt]
细胞定位	Cytoplasm. [UniProt]
预测分子量	44 kDa
翻译后修饰	Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation. [UniProt]

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