anti-TTF1 antibody [SQab20219]
anti-TTF1 antibody [SQab20219] for IHC-Formalin-fixed paraffin-embedded sections and Human
|Recombinant Rabbit Monoclonal antibody [SQab20219] recognizes TTF1
|Synthetic peptide within aa. 50-150 of Human TTF1.
|Transcription termination factor 1; TTF-1; RNA polymerase I termination factor; Transcription termination factor I; TTF-I
|IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C - 25°C) for 30 minutes.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|Purification with Protein A.
|PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.
|0.01% Sodium azide
|40% Glycerol and 0.05% BSA
|For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
|For laboratory research only, not for drug, diagnostic or other use.
|transcription termination factor, RNA polymerase I
|This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]
|Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. [UniProt]
|Nucleus. Nucleus, nucleolus. [UniProt]
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