ARG62638
anti-TSP1 / Thrombospondin 1 antibody [A4.1]
anti-TSP1 / Thrombospondin 1 antibody [A4.1] for Flow cytometry,Functional study,ICC/IF,Western blot and Human,Bovine
Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [A4.1] recognizes TSP1 / Thrombospondin 1 |
|---|---|
| 反应物种 | Hu, Bov |
| 应用 | FACS, FuncSt, ICC/IF, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | A4.1 |
| 同位型 | IgM |
| 靶点名称 | TSP1 / Thrombospondin 1 |
| 抗原 | Calcium-replete, native purified human TSP from the supernatant of thrombin activated platelets. |
| 偶联标记 | Un-conjugated |
| 別名 | TSP1; THBS; THBS-1; Thrombospondin-1; TSP-1; TSP |
应用说明
| 应用说明 | WB: 1 - 2 µg/ml * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites fluid by ammonium sulfate precipitation. |
| 缓冲液 | 10mM PBS (pH 7.4), 0.2% BSA and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 0.2% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | THBS1 |
| 全名 | thrombospondin 1 |
| 背景介绍 | The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 129 kDa |
克隆号文献
Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss.
ICC/IF / Human
Oxidative stress-induced attenuation of thrombospondin-1 expression in primary rat astrocytes.
WB / Rat
Role of thrombospondin 1 in macrophage inflammation in dysferlin myopathy.
BL / Human
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
WB / Human
Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cells.
WB / Mouse
Angiostatic factors normally restrict islet endothelial cell proliferation and migration: implications for islet transplantation.
BL / Rat
PPARalpha deficiency in inflammatory cells suppresses tumor growth.
BL / Mouse
Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts.
IHC / Human
