ARG22283
anti-TRPV3 antibody [S15-4]
anti-TRPV3 antibody [S15-4] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [S15-4] recognizes TRPV3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 特异性 | Detects ~70kDa. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S15-4 |
| 同位型 | IgG2a |
| 靶点名称 | TRPV3 |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide around aa. 774-791 (C-terminus) of Rat TrpV3 |
| 偶联标记 | Un-conjugated |
| 別名 | VRL3; VRL-3; TrpV3; Transient receptor potential cation channel subfamily V member 3; OLMS; Vanilloid receptor-like 3; FNEPPK2 |
应用说明
| 应用建议 |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8K424 Mouse Transient receptor potential cation channel subfamily V member 3 Swiss-port # Q8NET8 Human Transient receptor potential cation channel subfamily V member 3 |
|---|---|
| 基因名称 | Trpv3 |
| 全名 | ransient receptor potential cation channel, subfamily V, member 3 |
| 背景介绍 | This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| 生物功能 | Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). [UniProt] |
| 细胞定位 | Membrane |
| 预测分子量 | 91 kDa |
检测图片 (1) Click the Picture to Zoom In
-
ARG22283 anti-TRPV3 antibody [S15-4] WB image
Western blot: Human cell lysates stained with ARG22283 anti-TRPV3 antibody [S15-4] at 1:1000 dilution.
