ARG67048
anti-TRPS1 antibody [SQab30333]
anti-TRPS1 antibody [SQab30333] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant rabbit Monoclonal antibody [SQab30333] recognizes TRPS1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30333 |
| 同位型 | IgG |
| 靶点名称 | TRPS1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human TRPS1 |
| 偶联标记 | Un-conjugated |
| Protein Full name | Zinc finger transcription factor Trps1 |
| 別名 | TRPS1, Transcriptional Repressor GATA Binding 1, LGCR, GC79, Tricho-Rhino-Phalangeal Syndrome Type I Protein, Zinc Finger Transcription Factor Trps1, Trichorhinophalangeal Syndrome I, Zinc Finger Protein GC79 |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Beast cancer |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UHF7 Human Zinc finger transcription factor Trps1 |
|---|---|
| 基因名称 | TRPS1 |
| 全名 | Transcriptional Repressor GATA Binding 1 |
| 背景介绍 | This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008] |
| 生物功能 | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. [UniProt] |
| 细胞定位 | Nucleus |
| 预测分子量 | 141 kDa |
| 翻译后修饰 | Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG67048 anti-TRPS1 antibody [SQab30333] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded breast cancer stained with ARG67048 anti-TRPS1 antibody [SQab30333].
