ARG44254
anti-TRPM2 antibody
anti-TRPM2 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Goat Polyclonal antibody recognizes TRPM2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Cow |
| 应用 | FACS, ICC/IF, IHC-P |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TRPM2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human TRPM2 (QQKQRPEQKIED) |
| 偶联标记 | Un-conjugated |
| 別名 | KNP3; Transient receptor potential cation channel subfamily M member 2; NUDT9H; EREG1; LTrpC2; TrpC7; EC 3.6.1.13; TRPC7; NUDT9L1; LTRPC2; LTrpC-2; Transient receptor potential channel 7; Long transient receptor potential channel 2; Estrogen-responsive element-associated gene 1 protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O94759 Human Transient receptor potential cation channel subfamily M member 2 |
|---|---|
| 基因名称 | TRPM2 |
| 全名 | transient receptor potential cation channel, subfamily M, member 2 |
| 背景介绍 | The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008] |
| 生物功能 | Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection. Cytoplasmic vesicle. Lysosome. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG44254 anti-TRPM2 antibody IHC-P image
Immunohistochemistry: Human Pancreas stained with ARG44254 anti-TRPM2 antibody at 3.75µg/ml dilution.
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ARG44254 anti-TRPM2 antibody ICC/IF image
Immunofluorescence: A431 stained with ARG44254 anti-TRPM2 antibody at 10µg/ml dilution.
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ARG44254 anti-TRPM2 antibody FACS image
Flow Cytometry: Jurkat stained with ARG44254 anti-TRPM2 antibody at 10µg/ml dilution.
