ARG46606
anti-TRIM30 / Rpt1 antibody
anti-TRIM30 / Rpt1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TRIM30 / Rpt1 |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TRIM30 / Rpt1 |
| 抗原物种 | Mouse |
| 抗原 | A 21 amino acid synthetic peptide within the last 50 amino acids of mouse TRIM30 / Rpt1. |
| 偶联标记 | Un-conjugated |
| 別名 | tripartite motif-containing 30; TRIM30; Rpt1; Rpt-1; Trim30; Rpt1; Tripartite motif-containing protein 30A; Down regulatory protein of interleukin-2 receptor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 105 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -656°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P15533 Mouse Tripartite motif-containing protein 30A |
|---|---|
| 基因名称 | Trim30 |
| 全名 | tripartite motif-containing 30 |
| 背景介绍 | Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of cytokine production; protein autoubiquitination; and regulation of pattern recognition receptor signaling pathway. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; heart; and limb. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Jul 2025] |
| 生物功能 | Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. [UniProt] |
| 细胞定位 | Cytoplasm; Nucleus. [UniProt] |
| 预测分子量 | 107 kDa |
