ARG44758

anti-TRIM25 antibody

anti-TRIM25 antibody for Immunoprecipitation and Human

概述

产品描述 Mouse Monoclonal antibody recognizes TRIM25
反应物种 Hu
应用 IP
宿主 Mouse
克隆 Monoclonal
同位型 IgG1
靶点名称 TRIM25
抗原物种 Human
偶联标记 Un-conjugated
別名 EC 6.3.2.19; ZNF147; EFP; Ubiquitin/ISG15-conjugating enzyme TRIM25; Tripartite motif-containing protein 25; Z147; E3 ubiquitin/ISG15 ligase TRIM25; EC 6.3.2.n3; Zinc finger protein 147; Estrogen-responsive finger protein; RNF147; RING finger protein 147

应用说明

应用建议
应用 推荐稀释比
IP10 µg/mL
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
纯化 Protein A purification
缓冲液 PBS with 0.09% sodium azide
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 7706 Human TRIM25

Swiss-port # Q14258 Human E3 ubiquitin/ISG15 ligase TRIM25

基因名称 TRIM25
全名 tripartite motif containing 25
背景介绍 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
生物功能 Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). [UniProt]
细胞定位 Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies. [UniProt]
预测分子量 71 kDa
翻译后修饰 Auto-ISGylated. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG44758 anti-TRIM25 antibody IP image

    Immunoprecipitation: A549 lysate immunoprecipitated with 2.5 µg of ARG44758 anti-TRIM25 antibody.