概述

产品描述	Rabbit Polyclonal antibody recognizes TRIB3
反应物种	Hu
应用	IP, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	TRIB3
抗原物种	Human
抗原	Synthetic peptide derived from Human TRIB3.
偶联标记	Un-conjugated
別名	C20orf97; NIPK; TRB-3; TRB3; Neuronal cell death-inducible putative kinase; SKIP3; SINK; Tribbles homolog 3; p65-interacting inhibitor of NF-kappa-B

应用说明

应用建议	应用 推荐稀释比 IP 1:20 WB 1:1000 - 1:5000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	293T
实际分子量	~ 40 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 57761 Human TRIB3 Swiss-port # Q96RU7 Human Tribbles homolog 3
基因名称	TRIB3
全名	tribbles pseudokinase 3
背景介绍	The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
生物功能	Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. [UniProt]
细胞定位	Nucleus. [UniProt]
预测分子量	40 kDa

检测图片 (1) Click the Picture to Zoom In