ARG41226
anti-TRAF4 antibody
anti-TRAF4 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TRAF4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Hm |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TRAF4 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 437-454 of Human TRAF4. (PKFISHQDIRKRNYVRDD) |
| 偶联标记 | Un-conjugated |
| 別名 | RNF83; Metastatic lymph node gene 62 protein; MLN62; MLN 62; CART1; RING finger protein 83; Cysteine-rich domain associated with RING and Traf domains protein 1; TNF receptor-associated factor 4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~ 54 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TRAF4 |
| 全名 | TNF receptor-associated factor 4 |
| 背景介绍 | This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. [UniProt] |
| 预测分子量 | 54 kDa |
| 翻译后修饰 | Polyubiquitinated, leading to its proteasomal degradation. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG41226 anti-TRAF4 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat lymphonodus tissue stained with ARG41226 anti-TRAF4 antibody.
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ARG41226 anti-TRAF4 antibody WB image
Western blot: Rat thymus, HeLa, Jurkat and HEPA cell lysates stained with ARG41226 anti-TRAF4 antibody.
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ARG41226 anti-TRAF4 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG41226 anti-TRAF4 antibody.
