ARG52449
anti-TR2 antibody
anti-TR2 antibody for Western blot and Human,Mouse,Rat
Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TR2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TR2 |
| 抗原物种 | Mouse |
| 抗原 | Fusion protein from the N-terminal region of mouse TR2 |
| 偶联标记 | Un-conjugated |
| 別名 | Testicular receptor 2; Nuclear receptor subfamily 2 group C member 1; TR2; Orphan nuclear receptor TR2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | Specific for the ~64 kDa TR2 protein in Western blots of testes and nuclear extracts from MEL cell lines. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Neat Serum |
| 缓冲液 | Neat serum |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NR2C1 |
| 全名 | nuclear receptor subfamily 2, group C, member 1 |
| 背景介绍 | Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008). |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 67 kDa |
| 翻译后修饰 | Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity). Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity). |
检测图片 (1) Click the Picture to Zoom In
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ARG52449 anti-TR2 antibody WB image
Western Blot: rat testes lysate showing specific immunolabeling of the ~ 64k TR2 protein stained with TR2 antibody (ARG52449).
