anti-TPO / Thyroid Peroxidase antibody [SQab21249]

anti-TPO / Thyroid Peroxidase antibody [SQab21249] for IHC-Formalin-fixed paraffin-embedded sections and Human


产品描述 Mouse Monoclonal antibody [SQab21249] recognizes TPO / Thyroid Peroxidase
反应物种 Hu
应用 IHC-P
宿主 Mouse
克隆 Monoclonal
克隆号 SQab21249
同位型 IgG
靶点名称 TPO / Thyroid Peroxidase
抗原物种 Human
抗原 Synthetic peptide corresponding to Human TPO / Thyroid Peroxidase.
偶联标记 Un-conjugated
別名 TPO; EC; TDH2A; Thyroid peroxidase; MSA; TPX


应用 推荐稀释比
IHC-P1:100 - 1:200
应用说明 IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05% BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 7173 Human TPO

Swiss-port # P07202 Human Thyroid peroxidase

基因名称 TPO
全名 thyroid peroxidase
背景介绍 This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
生物功能 Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). [UniProt]
细胞定位 Membrane; Single-pass type I membrane protein. Isoform 3: Cell surface. [UniProt]
预测分子量 103 kDa
翻译后修饰 Glycosylated.

Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.

Cleaved in its N-terminal part. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG66882 anti-TPO / Thyroid Peroxidase antibody [SQab21249] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human thyroid gland tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66882 anti-TPO / Thyroid Peroxidase antibody [SQab21249] for 30 min at RT.