ARG66511
anti-TPO / Thyroid Peroxidase antibody
anti-TPO / Thyroid Peroxidase antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes TPO / Thyroid Peroxidase |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2b, kappa |
| 靶点名称 | TPO / Thyroid Peroxidase |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human TPO / Thyroid Peroxidase. |
| 偶联标记 | Un-conjugated |
| 別名 | TPO; EC 1.11.1.8; TDH2A; Thyroid peroxidase; MSA; TPX |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Citric acid buffer (pH 6.0) was used. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TPO |
| 全名 | thyroid peroxidase |
| 背景介绍 | This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011] |
| 生物功能 | Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. Isoform 3: Cell surface. [UniProt] |
| 预测分子量 | 103 kDa |
| 翻译后修饰 | Glycosylated. Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface. Cleaved in its N-terminal part. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG66511 anti-TPO / Thyroid Peroxidase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human follicular thyroid carcinoma stained with ARG66511 anti-TPO / Thyroid Peroxidase antibody at 1:200 (4°C, overnight). Antigen Retrieval: Citric acid buffer (pH 6.0) was used.
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ARG66511 anti-TPO / Thyroid Peroxidase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human papillary thyroid carcinoma stained with ARG66511 anti-TPO / Thyroid Peroxidase antibody at 1:200 (4°C, overnight). Antigen Retrieval: Citric acid buffer (pH 6.0) was used.
